MAB4500C
MilliporeSigma™ Mouse anti-B23 (Ascites Free), Clone: 3C9,
Manufacturer: MilliporeSigma™
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | MAB4500C-Each-of-1 | In Stock | ₹ 37,825.00 |
MAB4500C - Each of 1
In Stock
Quantity
1
Base Price: ₹ 37,825.00
GST (18%): ₹ 6,808.50
Total Price: ₹ 44,633.50
Antigen
B23 (Ascites Free)
Classification
Monoclonal
Formulation
Purified mouse monoclonal IgMκ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Symbols
NPM1; NPM
Immunogen
Daudi nuclear extract.
Quantity
100 μg
Research Discipline
Neuroscience
Gene ID (Entrez)
NP_002511
Content And Storage
Stable for one year at 2°C to 8°C from date of receipt.
Isotype
IgM κ
Applications
Immunocytochemistry, Immunohistochemistry, Immunoprecipitation, Western Blot
Clone
3C9
Gene Accession No.
P06748
Host Species
Mouse
Purification Method
Protein G Purified
Regulatory Status
RUO
Primary or Secondary
Primary
Target Species
Human, Monkey
Form
Purified
Related Products
Description
- Specifically detects B23 (Ascites Free) clone: 3C9 in Human, Monkey samples, and it is validated for Immunocytochemistry, Immunohistochemistry, Immunoprecipitation, Western Blotting Nucleophosmin (UniProt P06748; also known as B23, NPM, Nucleolar phosphoprotein B23, Nucleolar protein NO38, Numatrin) is encoded by the NPM1 (also known as NPM) gene (Gene ID 4869) in human
- Nucleophosmin (NPM) is a nucleolar protein that plays a role in ribosome biogenesis, nucleocytoplasmic transport, centrosome duplication, embryonic development, histone chaperone function, and transcriptional regulation
- NPM is phosphorylated by Cdk2-cyclin E on Thr199 which causes the dissociation of NPM from the centrosome to allow duplication during the cell cycle
- NPM is phosphorylated by the mitotic Cdk1-cyclin B complex on Thr234/237 during mitosis, resulting in its reassociation with the duplicated centrosomes
- The human NPM1 gene transcribes three alternatrively spliced isoforms, isoforms 1&2 contain a nucleolar localization signal at their C-terminal end (W288/290 of isoform 1 and W259/261 of isoform 2), which is missing in the spliced isoform 3
- In addition, a nuclear export signal is introduced, rendering the aberrant cytoplasmic location of this spliced isoform (NPMc).