MilliporeSigma™ anti-ING4 Clone: BTIM-4,
Manufacturer: MilliporeSigma™
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | MABE1156MI-Each-of-1 | In Stock | ₹ 41,813.98 |
MABE1156MI - Each of 1
In Stock
Quantity
1
Base Price: ₹ 41,813.98
GST (18%): ₹ 7,526.516
Total Price: ₹ 49,340.496
Antigen
ING4
Classification
Monoclonal
Conjugate
Unconjugated
Gene Accession No.
Q9UNL4
Host Species
Mouse
Purification Method
Protein G purified
Regulatory Status
RUO
Primary or Secondary
Primary
Test Specificity
Clone BTIM-4 reacts with human and murine ING4, but not human ING1, ING2, or ING5 (Byron, S.A., et al. (2012). PLoS One. 7(10):e46823). Expected to react with human ING4 isoform 1 (ING4_v1) and isoform 8 (deltaEx6A). Reactivity toward human ING4 spliced isoform 2 to 7 has not been tested.
Content And Storage
2°C to 8°C for one year from date of shipment
Isotype
IgG1 κ
Applications
Immunocytochemistry, Immunohistochemistry, Western Blot
Clone
BTIM-4
Formulation
Purified mouse monoclonal IgG1κ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Symbols
ING4, My036
Immunogen
His-tagged recombinant protein corresponding to the N-terminal half of human ING4.
Quantity
100 μg
Research Discipline
Epigenetics, Nuclear Function
Gene ID (Entrez)
NP_001121054
Target Species
Human, Mouse
Form
Purified
Related Products
Description
- Specifically detects ING4 Clone: BTIM-4 in Human, Mouse samples, and it is validated for Immunocytochemistry, Immunohistochemistry, Western Blotting Inhibitor of growth protein 4 (UniProt Q9UNL4; also known as Brain my036 protein, Candidate tumor suppressor p33 ING1 homolog, p29ING4) is encoded by the ING4 gene (ORF My036; Gene ID 51147) in human
- The inhibitor of growth (ING) family tumor suppressor ING4 is a transcription regulator that exerts its function via chromatin remodeling
- ING4 to targets the trimethylated lysine 4 of histone H3 (H3K4me3) via its conserved plant homeodomain (PHD) finger motif and is shown to associate with the HBO1/JADE histone acetyltransferase (HAT) complex
- ING4 is shown to play a role in many cancer-related cellular processes, including cell proliferation, apoptosis, migration, angiogenesis, contact inhibition, DNA damage response, and hypoxia
- Both gene deletion and reduced ING4 expression are reported in cancers of diverse tissue types, although ING4 knockout by itself does not cause increased spontaneous tumor formation in mice
- Immunohistochemistry analysis of breast cancer tissues shows that 34% of tumors expressed undetectable to low levels of ING4
- In addition, ING4 downregulation inversely correlates with an increase in NF-κB activation and NF-κB-dependent genes expression in primary breast tumors.