CD318 (CD6L), Mouse anti-Human, Clone: 3A11, Millipore Sigma™
Manufacturer: Fischer Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | MABF2119100-Each-of-1 | In Stock | ₹ 44,937.88 |
MABF2119100 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 44,937.88
GST (18%): ₹ 8,088.818
Total Price: ₹ 53,026.698
Antigen
CD318 (CD6L)
Classification
Monoclonal
Conjugate
Unconjugated
Formulation
Purified mouse monoclonal antibody IgG1 in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene Symbols
CDCP1;TRASK
Immunogen
HBL-100 human mammary gland epithelial cells.
Quantity
100 μg
Research Discipline
Inflammation & Immunology
Gene ID (Entrez)
NP_073753.3
Target Species
Human
Form
Purified
Applications
Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Clone
3A11
Dilution
Immunoprecipitation Analysis: A representative lot immunoprecipitated CD318 (CD6L) in Immunoprecipitation applications (Saifullah, M.K., et. al. (2004). J Immunol. 173(10):6125-33; Enyindah-Asonye, G., et. al. (2017). Proc Natl Acad Sci U S A. 114(33):E6912-E6921).Immunohistochemistry (Paraffin) Analysis: A representative lot detected CD318 (CD6L) in Immunohistochemistry applications (Enyindah-Asonye, G., et. al. (2017). Proc Natl Acad Sci U S A. 114(33):E6912-E6921).Western Blotting Analysis: A representative lot detected CD318 (CD6L) in Western Blotting applications (Saifullah, M.K., et. al. (2004). J Immunol. 173(10):6125-33; Enyindah-Asonye, G., et. al. (2017). Proc Natl Acad Sci U S A. 114(33):E6912-E6921).Flow Cytometry Analysis: A representative lot detected CD318 (CD6L) in Flow Cytometry applications (Saifullah, M.K., et. al. (2004). J Immunol. 173(10):6125-33; Enyindah-Asonye, G., et. al. (2017). Proc Natl Acad Sci U S A. 114(33):E6912-E6921).
Gene Alias
CUB domain-containing protein 1;Membrane glycoprotein gp140;Subtractive immunization M plus HEp3-associated 135 kDa protein;SIMA135;Transmembrane and associated with src kinases;CD6L
Host Species
Mouse
Purification Method
Protein G purified
Regulatory Status
RUO
Primary or Secondary
Primary
Test Specificity
Clone 3A11 specifically detects CD318 in human cells. It targets an epitope with in the extracellular domain.
Content And Storage
Stable for 1 year at 2-8°C from date of receipt.
Isotype
IgG1 κ
Related Products
Description
- Anti-CD318 (CD6L), clone 3A11, Cat
- No
- MABF2119, is a mouse monoclonal antibody that detects CD318 (CD6L) and has been tested for use in Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Paraffin), Immunoprecipitation, and Western Blotting
- CUB domain-containing protein 1 (UniProt: Q9H5V8; also known as Membrane glycoprotein gp140, Subtractive immunization M plus HEp3-associated 135 kDa protein, SIMA135, Transmembrane and associated with Src kinases, CD318, CD6L) is encoded by the CDCP1 (also known as TRASK) gene (Gene ID:64866) in human
- CD318 is a single-pass membrane protein (isoform 1) that serves as a ligand for CD6
- It is highly expressed in mitotic cells and has low expression during interphase
- It is detected in high levels in skeletal muscle and colon tissue and in lower levels in kidney, placenta, lungs, and small intestine
- Its levels are shown to be up-regulated in several human cancer tissues
- It is also expressed in high levels in synovial tissues where it participates in CD6-dependent adhesion of T cells to synovial fibroblasts
- CD318 is shown to be chemoattractive to T cells and levels of soluble CD318 are increased in the synovial fluid from patients with rheumatoid arthritis and juvenile inflammatory arthritis
- CD318 is synthesized with a signal peptide (aa 1-29), which is cleaved off in the mature form
- It has an extracellular domain (aa 30-667), a transmembrane domain (aa 668-688), and a cytoplasmic domain (aa 689-836)
- Three isoforms of CD318 have been described that are produced by alternative splicing
- (Ref.: Enyindah-Asonye, G., et al
- (2017)
- Proc
- Natl
- Acad
- Sci
- USA 114(33); E6912-E6921).