MABF803MI
MilliporeSigma™ anti-CD11b Red Fluor 710, Clone: M1/70,
Manufacturer: Fischer Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | MABF803MI-Each-of-1 | In Stock | ₹ 16,846.81 |
MABF803MI - Each of 1
In Stock
Quantity
1
Base Price: ₹ 16,846.81
GST (18%): ₹ 3,032.426
Total Price: ₹ 19,879.236
Antigen
CD11b
Classification
Monoclonal
Conjugate
Red Fluor 710
Gene Accession No.
P05555
Host Species
Rat
Purification Method
Purified by size-exclusion chromatography
Regulatory Status
RUO
Primary or Secondary
Primary
Content And Storage
2°C to 8°C undiluted for one year from date of shipment protected from light; Do not freeze
Isotype
IgG2b κ
Applications
Flow Cytometry
Clone
M1/70
Formulation
Purified Rat monoclonal containing 10mM NaH2PO4, 150mM NaCl, 0.09% NaN3, 0.1% gelatin, pH 7.2.
Gene Symbols
Itgam
Immunogen
Proprietary immunogen
Quantity
25 μg
Research Discipline
Inflammation, Immunology
Target Species
Human, Mouse
Form
Purified
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Description
- Specifically detects CD11b Clone: M1/70 in Human, Mouse samples, and it is validated for Flow Cytometry The M1/70 antibody reacts with human and mouse CD11b, also known as integrin alpha M
- This 165-170kDa cell surface glycoprotein is part of a family of integrin receptors that mediate adhesion between cells (cell-cell) and components of the extracellular matrix, e.g
- fibrinogen (cell-matrix)
- In addition, integrins are active signaling receptors which recruit leukocytes to inflammatory sites and promote cell activation
- Complete, functional integrin receptors consist of distinct combinations of integrin chains which are differentially expressed
- Integrin alphaM (CD11b) assembles with Integrin beta-2 (CD18) into a receptor known as Macrophage Antigen-1 (Mac-1) or complement receptor type 3 (CR3)
- This receptor binds and induces intracellular signaling through ICAM-1 on endothelial cells and can also facilitate removal of iC3b bearing foreign cells.The M1/70 antibody is widely used as a marker for CD11b expression on mouse macrophages, granulocytes, neutrophils, and NK cells
- The antibody is also reported to be cross-reactive for Rhesus macaque CD11b.