MilliporeSigma™ Rat anti-FcgRII/III Anibody, Clone: Ab93,
Manufacturer: MilliporeSigma™
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | MABF838MI-Each-of-1 | In Stock | ₹ 36,371.63 |
MABF838MI - Each of 1
In Stock
Quantity
1
Base Price: ₹ 36,371.63
GST (18%): ₹ 6,546.893
Total Price: ₹ 42,918.523
Antigen
FcgRII/III Anibody
Classification
Monoclonal
Formulation
Purified rat monoclonal IgG2aκ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl without preservatives.
Gene Symbols
Fcgr3; Fcgr2; Fcgr2b; Ly-17
Immunogen
Whole cells expressing mouse FcgRII/III.
Quantity
100 μg
Research Discipline
Inflammation and Immunology
Gene ID (Entrez)
CD32: NP_034317
Content And Storage
Stable for one year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles which may damage IgG and affect product performance.
Isotype
IgG2a κ
Applications
Functional Assay, Flow Cytometry, Immunocytochemistry
Clone
Ab93
Gene Accession No.
P08508; P08101
Host Species
Rat
Purification Method
Protein G Purified
Regulatory Status
RUO
Primary or Secondary
Primary
Target Species
Mouse
Form
Purified
Related Products
Description
- Specifically detects FcgRII/III Anibody clone: Ab93 in Mouse samples, and it is validated for Activity Assay, Flow Cytometry, Immunocytochemistry Murine low affinity IgG Fc region receptor FcγRII and FcγRIII (UniProt P08101 and P08508, respectively) are encoded by the Fcgr2 (also known as Fcgr2b, Ly-17) and Fcgr3 gene, respectively
- Four different classes of IgG Fc receptors (FcγRs) have been reported: FcγRI/CD32b, FcγRII/CD16, FcγRIII/CD16.2, and FcγRIV/CD64
- FcγRII, FcγRIII, and FcγRIV (UniProt P08101, P08508, and Q8R477, respectively) are low-affinity receptors for monomeric IgG, whereas FcγRI (UniProt P26151) is the only high-affinity FcγR
- FcγRs play important roles in inflammatory cell activation, clearance, presentation of antigen, and maintenance of IgG homeostasis
- In addition to binding immune complex (IC), FcγRs have been shown to bind to non-IgG ligands
- For example, FcγRII is shown to bind oxLDL, while FcγRIII binding to an E
- coli component negatively regulates the function of macrophage receptor with collagenous structure (MARCO)
- FcyRII activation is also reported to transduce a negative regulatory signal against CD38 cross-linking-induced proliferation of resting mature B cells.