MilliporeSigma™ anti-IDO-1 Clone: 4B7,
Manufacturer: MilliporeSigma™
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | MABF850MI-Each-of-1 | In Stock | ₹ 36,371.63 |
MABF850MI - Each of 1
In Stock
Quantity
1
Base Price: ₹ 36,371.63
GST (18%): ₹ 6,546.893
Total Price: ₹ 42,918.523
Antigen
IDO-1
Classification
Monoclonal
Conjugate
Unconjugated
Gene Accession No.
P28776
Host Species
Mouse
Purification Method
Protein G purified
Regulatory Status
RUO
Primary or Secondary
Primary
Test Specificity
Target specificity of clone 4B7 has been confirmed by both immunohistochemistry and Western blotting using tissue samples from wild-type and Ido1-knockout mice (Thomas, S., et al. (2014). J. Cell. Biochem. 115(2):391-396).
Content And Storage
2°C to 8°C for one year from date of shipment
Isotype
IgG1 κ
Applications
Immunohistochemistry (Paraffin), Western Blot
Clone
4B7
Formulation
Purified mouse monoclonal IgG1κ in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Symbols
Ido1, Ido, Indo
Immunogen
KLH-conjugated linear peptide corresponding to the N-terminal region of mouse IDO-1.
Quantity
100 μg
Research Discipline
Inflammation, Immunology
Gene ID (Entrez)
NP_032350
Target Species
Mouse, Rat
Form
Purified
Related Products
Description
- Specifically detects IDO-1 Clone: 4B7 in Mouse, Rat samples, and it is validated for Immunohistochemistry (Paraffin), Western Blotting Indoleamine 2,3-dioxygenase 1 (EC 1.13.11.52; UniProt P28776; also known as IDO-1, indole 2,3-dioxygenase, Indoleamine-pyrrole 2,3-dioxygenase) is encoded by the Ido1 (also known as Ido, Indo) gene (Gene ID 15930) in murine species
- Indoleamine 2,3-dioxygenase-1 (IDO1) is a heme containing enzyme that catalyzes the rate-limiting step in tryptophan catabolism to N-formyl-kynurenine
- The reduction in local tryptophan and the upregulated immunomodulatory tryptophan metabolites form the basis of IDO-dependent regulation of inflammation and immunity
- IDO is reported to support carcinogenesis by modulating tissue microenvironment inflammatory responses
- IDO is also reported to mediate immune escape in cancer by suppressing the function of T effector cells and promote the differentiation of T regulatory cells.