MABS518MI
MilliporeSigma™ Mouse anti-CBS, Clone: 9F3.2,
Manufacturer: MilliporeSigma™
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | MABS518MI-Each-of-1 | In Stock | ₹ 40,292.08 |
MABS518MI - Each of 1
In Stock
Quantity
1
Base Price: ₹ 40,292.08
GST (18%): ₹ 7,252.574
Total Price: ₹ 47,544.654
Antigen
CBS
Classification
Monoclonal
Formulation
Purified mouse monoclonal IgG2aκ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Symbols
CBS
Immunogen
Recombinant protein corresponding to the N-terminal of human CBS.
Quantity
100 μg
Research Discipline
Signaling
Gene ID (Entrez)
NP_001171479
Content And Storage
Stable for one year at 2°C to 8°C from date of receipt.
Isotype
IgG2a κ
Applications
Immunohistochemistry (Paraffin), Western Blot
Clone
9F3.2
Gene Accession No.
P35520
Host Species
Mouse
Purification Method
Protein G Purified
Regulatory Status
RUO
Primary or Secondary
Primary
Target Species
Human
Form
Purified
Related Products
Description
- Specifically detects CBS clone: 9F3.2 in Human samples, and it is validated for Immunohistochemistry (Paraffin), Western Blotting Cystathionine beta-synthase (EC 4.2.1.22; UniProt P35520; also known as beta-thionase, Methylcysteine synthase, Serine sulfhydrase) is encoded by the CBS (also known as HIP4) gene (Gene ID 875) in human
- Cystathionine beta-synthase catalyzes the trans-sulfuration of homocysteine and serine to form the cysteine precursor cystathionine in the folate pathway
- Cysteine is an essential substrate for the biosynthesis of glutathione, a major endogenous antioxidant
- CBS deficiency results in altered sulfur metabolism and homocystinuria characterized by increased urinary homocystine and methionine
- The clinical features of untreated homocystinuria due to CBS deficiency include myopia, ectopia lentis, mental retardation, skeletal anomalies resembling Marfan syndrome, and thromboembolic events.