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MABS83025UG

Acetyl CoA Carboxylase 1, Mouse anti-Mouse, Human, Clone: 7H4.2, Millipore Sigma™

Manufacturer: MilliporeSigma

Select a Size

Pack Size SKU Availability Price
Each of 1 MABS83025UG-Each-of-1 In Stock ₹ 17,118.26

MABS83025UG - Each of 1

₹ 17,118.26

In Stock

Quantity

1

Base Price: ₹ 17,118.26

GST (18%): ₹ 3,081.287

Total Price: ₹ 20,199.547

Antigen

Acetyl CoA Carboxylase 1

Classification

Monoclonal

Conjugate

Unconjugated

Formulation

Purified mouse monoclonal antibody IgG2b in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Gene Symbols

ACACA;ACAC;ACC1;ACCA

Immunogen

GST/His-tagged recombinant fragment corresponding to 86 amino acids from the C-terminal end of human Acetyl-CoA carboxylase 1.

Quantity

25 μg

Research Discipline

Signaling

Test Specificity

Clone 7H4.2 detects acetyl-CoA carboxylase 1 in human. It targets an epitope within 86 amino acids from the C-terminal end.

Content And Storage

Stable for 1 year at 2-8°C from date of receipt.

Isotype

IgG2b

Applications

Immunohistochemistry (Paraffin), Western Blot

Clone

7H4.2

Dilution

Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected Acetyl CoA Carboxylase 1 in human tonsil, human testis, and human cervical cancer tissue. Western Blotting Analysis: 0.5μg/mL from a representative lot detected Acetyl CoA Carboxylase 1 in 10μg of NIH/3T3 cell lyate.

Gene Alias

ACC1;ACC-alpha

Host Species

Mouse

Purification Method

Protein G purified

Regulatory Status

RUO

Primary or Secondary

Primary

Target Species

Mouse, Human

Form

Purified

Description

  • Anti-Acetyl CoA Carboxylase 1 Antibody, clone 7H4.2, Cat
  • No
  • MABS830, is a mouse monoclonal antibody that targets Acetyl CoA Carboxylase 1 and has been tested for use in Immunohistochemistry (Paraffin) and Western Blotting
  • Acetyl-CoA carboxylase 1 (UniProt: Q13085; also known as ACC1, ACC-alpha) is encoded by the ACACA (also known as ACAC, ACC1, ACCA) gene (Gene ID: 31) in human
  • It catalyzes the rate-limiting reaction in the biogenesis of long-chain fatty acids
  • ACC1 is a multi-subunit, biotin-dependent enzyme that catalyzes carboxylation of acetyl-CoA to produce malonyl-CoA through its two catalytic activities, biotin carboxylase (BC) and carboxyltransferase (CT)
  • The activity of ACC can be controlled at the transcriptional level as well as by small molecule modulators and covalent modification
  • Two isoforms fof ACC have been reported, alpha and beta that are encoded by two different genes
  • ACC-alpha is highly enriched in lipogenic tissues
  • ACC1 levels are regulated under long term control at the transcriptional and translational levels and under short term regulation by the phosphorylation/dephosphorylation of targeted serine residues and by allosteric transformation by citrate or palmitoyl-CoA
  • ACC1 activity is inhibited upon phosphorylation, which occurs when glucagon or epinephrine binds to the receptors or when the energy status of the cell is low, leading to the activation of the AMP-activated protein kinase
  • The presence of fatty acids inhibits the activities of ACC1
  • ACC is considered as an important target in the design of new anti-obesity drugs.