This mouse monoclonal TKS5, Mouse anti-Human, Clone: 9H2.1, Millipore Sigma™
Manufacturer: MilliporeSigma
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | MABT33725UG-Each-of-1 | In Stock | ₹ 16,643.00 |
MABT33725UG - Each of 1
In Stock
Quantity
1
Base Price: ₹ 16,643.00
GST (18%): ₹ 2,995.74
Total Price: ₹ 19,638.74
Antigen
This mouse monoclonal TKS5
Classification
Monoclonal
Conjugate
Unconjugated
Gene Alias
Adapter protein TKS5;Five SH3 domain-containing protein;SH3 multiple domains protein 1;Tyrosine kinase substrate with five SH3 domains;SH3 and PX domain-containing protein 2A
Host Species
Mouse
Purification Method
Protein G purified
Regulatory Status
RUO
Primary or Secondary
Primary
Target Species
Human
Form
Purified
Applications
Western Blot
Clone
9H2.1
Formulation
Purified mouse monoclonal antibody IgG1 in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene Symbols
SH3PXD2A;FISH;KIAA0418;SH3MD1;TKS5
Immunogen
GST/His-tagged recombinant fragment corresponding to 91 amino acids from the C-terminal half of human SH3 and PX domain-containing protein 2A (Adapter protein TKS5).
Quantity
25 μg
Research Discipline
Cell Structure
Test Specificity
Clone 9H2.1 detects SH3 and PX domain-containing protein 2A (adapter protein TKS5) in human cells. It targets and epitope with in 91 amino acids crom the C-terminal half.
Content And Storage
Stable for 1 year at 2-8°C from date of receipt.
Isotype
IgG1 κ
Related Products
Description
- This mouse monoclonal Anti-TKS5, clone 9H2.1, Cat
- No
- MABT337, is a mouse monoclonal antibody that detects SH3 and PX domain-containing protein 2A (TKS5) and has been tested for use in Western Blotting
- SH3 and PX domain-containing protein 2A (UniProt: Q5TCZ1; also known as Adapter protein TKS5, Five SH3 domain-containing protein, SH3 multiple domains protein 1, Tyrosine kinase substrate with five SH3 domains) is encoded by the SH3PXD2A (also known as FISH, KIAA0418, SH3MD1, TKS5) gene (Gene ID: 9644) in human
- Adapter protein TKS5 is a scaffolding protein that is required for podosome formation, degradation of the extracellular matrix, and for invasion in some cancer cells
- Three isoforms of TKS5 have been described that are produced by alternative splicing
- TKS5 is a cytoplasmic protein in normal cells, but it localizes to podosomes in SRC-transformed cells
- It is found in several cancer cell lines, particularly invasive breast carcinomas and melanomas
- TKS5 contains one PX (phx homology) domain and five SH3 domains
- The PX domain is required for podosome localization because of its ability to bind phosphoinosiltols, such as PtdIns3P and PtdIns(3,4)P2 and to lesser extent PtdIns5P and PtdIns(3,5)P2
- Its binding with ADAM12, ADAM15 and ADAM19 is mediated by the fifth SH3 domain
- The intramolecular interaction of the PX domain with the third SH3 domain maintains the protein in the cytoplasm and phosphorylation disrupts this interaction, resulting in the redistribution of the protein from cytoplasm to the perimembrane region.