MABT388MI
MilliporeSigma™ Mouse anti-ADAM 17, Clone: 16C11.1,
Manufacturer: MilliporeSigma™
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | MABT388MI-Each-of-1 | In Stock | ₹ 40,292.08 |
MABT388MI - Each of 1
In Stock
Quantity
1
Base Price: ₹ 40,292.08
GST (18%): ₹ 7,252.574
Total Price: ₹ 47,544.654
Antigen
ADAM 17
Classification
Monoclonal
Formulation
Purified mouse monoclonal IgG1κ in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Symbols
ADAM17; CSVP; TACE
Immunogen
GST-tagged recombinant protein corresponding to human ADAM 17.
Quantity
100 μg
Research Discipline
Cell Structure
Gene ID (Entrez)
NP_003174
Content And Storage
Stable for one year at 2°C to 8°C from date of receipt.
Isotype
IgG1 κ
Applications
Immunohistochemistry (Paraffin), Western Blot
Clone
16C11.1
Gene Accession No.
P78536
Host Species
Mouse
Purification Method
Protein G Purified
Regulatory Status
RUO
Primary or Secondary
Primary
Target Species
Human
Form
Purified
Related Products
Description
- Specifically detects ADAM 17 clone: 16C11.1 in Human samples, and it is validated for Immunohistochemistry (Paraffin), Western Blotting Disintegrin and metalloproteinase domain-containing protein 17 (EC 3.4.24.86; UniProt P78536; also known as ADAM 17, CD156b, Snake venom-like protease
- TNF-alpha convertase, TNF-alpha-converting enzyme, Tumor necrosis factor alpha-converting enzyme) is encoded by the ADAM17 (also known as CD156B, CSVP, NISBD, NISBD1, TACE) gene (Gene ID 6868) in human
- Originally described as a TNF–alpha converting enzyme, ADAM17 is known to process the cleavage of many transmembrane proteins, including membrane-anchored cytokines, cell adhesion molecules, receptors, ligands, and enzymes
- ADAM17 was the first 'sheddase' identified
- ADAM17 activity is regulated by multiple post-translational modifications
- It has three phosphorylation sites on its C-terminal cytoplasmic domain (T735, S791, and (S819)
- ERK1/2-mediated T735 phosphorylation is reported to regulate ADAM17 maturation and surface expression
- ADAM 17 is initially translated in its prepro-form and subsequent cleavages of the signal (aa 1-17) and propeptide (18-214) sequences produces the 610 aa mature ADAM 17 (aa 215-824).