MilliporeSigma™ Rabbit anti-VE-Cadherin, Clone: Vli37,
Manufacturer: MilliporeSigma™
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | MABT886-Each-of-1 | In Stock | ₹ 40,292.08 |
MABT886 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 40,292.08
GST (18%): ₹ 7,252.574
Total Price: ₹ 47,544.654
Antigen
VE-Cadherin
Classification
Monoclonal
Formulation
Rabbit monoclonal IgG in supernatant with 0.05% sodium azide.
Gene Symbols
Cdh5
Immunogen
Linear peptide corresponding to the C-terminal cytoplasmic domain sequence of mouse VE-Cadherin.
Quantity
100 μL
Research Discipline
Cell Structure
Gene ID (Entrez)
NP_033998.2
Content And Storage
Stable for one year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles which may damage IgG and affect product performance.
Isotype
IgG
Applications
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Clone
Vli37
Gene Accession No.
P55284
Host Species
Rabbit
Purification Method
Unpurified
Regulatory Status
RUO
Primary or Secondary
Primary
Target Species
Bovine, Mouse
Form
Supernatant
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Description
- Specifically detects VE-Cadherin clone: Vli37 in Bovine, Mouse samples, and it is validated for Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blotting Cadherin-5 (UniProt P55284; also known as Vascular endothelial cadherin, VE-Cad, VE-cadherin, VEcad, CD144) is encoded by the Cdh5 gene (Gene ID 12562) in murine species
- Cadherins (calcium-dependent adhesion) are type-1 transmembrane proteins that form adherens junctions in tissues and play important roles in mediating cell adhesion
- Cadherins are designated with a prefix that specifies their tissue association
- Vascular endothelial-cadherin (VE-cadherin) is the transmembrane component of the endothelial adherens junction between vascular endothelial cells (ECs) and plays a pivotal role in endothelium integrity and in the control of vascular permeability
- One characteristic of VEGF-induced vascular permeability is the phosphorylation of VE-cadherin, which leads to VE-cadherin internalization and the destabilization of adherens junctions
- Likewise, VE-cadherin overexpression is shown to decrease the permeability of endothelial monolayers in vitro
- VE-cadherin is initially produced with a signal peptide (a.a
- 1-24) and a propeptide (a.a
- 25-45) sequence, the removal of which yields tthe mature protein containing a large extracellular region (a.a
- 46-599) with five cadherine repeats (a.a
- 46-149, 150-256, 257-371, 372-476, 477-593), followed by a transmembrane segment (a.a
- 600-620) and a cytoplasmic domain (a.a
- 621-784).