Fetal Hemoglobin Monoclonal Antibody (HBF-1), PE, Invitrogen™

Description

• R-phycoerythrin (PE) is a stable and highly soluble phycobiliprotein which provides maximal absorbance and fluorescence without susceptibility to internal or external fluorescence quenching, thus providing an exceptional quantum yields and molar extinction coefficients
• This antibody specifically recognizes fetal hemoglobin found in fetal erythrocytes
• Hemorrhage of cells from an Rh+ fetus into the circulation of an Rh- mother may result in the formation of Rh-reactive antibodies in the mother
• Rh hemolytic anemia in a subsequent Rh+ fetus may result from placental transfer of antibodies formed in the mother to the fetus
• Although the volume of fetal erythrocytes found in the maternal circulation during pregnancy and immediately post-partum is reported to be small and of uncertain clinical significance in many cases, substantial hemorrhage may result from a number of causes including fetal or maternal trauma and placental defects
• Erythrocytes containing fetal hemoglobin may be found in individuals of any age, but with lower amounts of fetal hemoglobin compared to fetal red cells
• These cells have been termed F cells
• High levels of F cells may also exist in adults with a heterogeneous group of genetic disorders of uncertain etiology, referred to as Hereditary Persistence of Fetal Hemoglobin
• Other clinical conditions causing significant levels of anemia may also result in elevated levels of F cells
• Several clinical conditions have been described with increased levels of F cells
• These conditions include hereditary anemic diseases such as sickle cell anemia and thalassemia major.