MS1511R7
Pds1 Ab-1 Mouse Monoclonal Antibody, Epredia™
Manufacturer: Fischer Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | MS1511R7-Each-of-1 | In Stock | ₹ 48,505.00 |
MS1511R7 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 48,505.00
GST (18%): ₹ 8,730.90
Total Price: ₹ 57,235.90
Antigen
Pds1 Ab-1
Classification
Monoclonal
Conjugate
Unconjugated
Immunogen
Human recombinant full length Pds1 protein
Regulatory Status
RUO
Primary or Secondary
Primary
Form
Prediluted
Applications
Immunohistochemistry (Paraffin), Western Blot
Clone
DCS-280
Host Species
Mouse
Quantity
7 mL
Research Discipline
Cancer and Tumor Biology
Target Species
Human
Isotype
IgG2a κ
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Description
- Pds1 is an anaphase inhibitor and plays important role in DNA damage and spindle check point pathways
- Pds1 inhibits sister chromatid separation by binding and inhibiting Esp1, cystein protease that causes cleavage of the cohesin Scc1 that binds the sister chromatids together
- Pds1 is responsible for targeting of Esp1 to nucleus and its binding to the spindle
- Degradation of Pds1 occurs shortly before anaphase, which liberates Esp1 and is a prerequisite for anaphase entry
- Pds1 is targeted for degradation by ubiquitination mediated by cyclosome/anaphase-promoting complex (APC) functioning as a ubiquitin ligase
- In response to DNA damage Chk1 phosphorylates Pds1 to stabilize it against the APC mediated destruction, hence preventing the entry of such a cell into anaphase
- Host Species: Mouse Clone: DCS-280 Isotype: IgG2a/κ Species Reactivity: Human
- Others not known
- Epitope: Not determined Immunogen: Human recombinant full-length Pds1 protein Molecular Weight: 42kDa Positive Control: HeLa cells, Tonsil Cellular Localization: Nuclear Recommended for: Immunohistochemistry (Formalin/paraffin) Western Blotting (Not verified) Note: USA: RUO; Int'l: RUO