CD74 Antibody (LN-2), Allophycocyanin/Cy7, Novus Biologicals™

CD74

Monoclonal

APC-Cyanine7

PBS with 0.05% Sodium Azide

CD74

SU-DHL-4 lymphoma cells were used as the immunogen for the CD74 antibody

0.1 mL

Primary

It recognizes a protein of ∼35kDa, identified as CD74 (Workshop IV). CD74 is a type II transmembrane protein which binds to the peptide binding groove of newly synthesized MHC class II alpha/beta heterodimers and prevents their premature association with endogenous polypeptides. CD74 is expressed primarily by antigen presenting cells, such as B-lymphocytes (from before the pre-B cell stage to before the plasma cell stage), macrophages, and monocytes, and many epithelial cells. Anti-CD74 stains predominantly germinal center lymphocytes and B-cell lymphomas, but rarely T-cell lymphomas. Anti-CD74 has been shown to be useful in differentiating atypical fibroxanthoma (-) from malignant fibrous histiocytoma (+).

Store at 4°C in the dark. Do not freeze.

Flow Cytometry

LN-2

Flow Cytometry

CD74 antigen, CD74 antigen (invariant polypeptide of major histocompatibility complex, classII antigen-associated), CD74 molecule, major histocompatibility complex, class II invariant chain, DHLAGgamma chain of class II antigens, HLA class II histocompatibility antigen gamma chain, HLADG, HLA-DR antigens-associated invariant chain, HLA-DR-gamma, Ia antigen-associated invariant chain, Ia-associated invariant chain, Ia-GAMMA, Ii, MHC HLA-DR gamma chain, p33

Mouse

Protein A or G purified

Immunology

972.0

Human, Mouse, Baboon, Rat (Negative)

IgG1 κ