MUC1 Antibody (SPM492), PE/Atto594, Novus Biologicals™

MUC1

Monoclonal

PE/ATTO 594

PBS with 0.05% Sodium Azide

MUC1

Breast Cancer Cell line ZR75-1

0.1 mL

Primary

This monoclonal antibody reacts with MUC1. The dominant epitope of this monoclonal antibody has not yet been determined. MUC1 is a large cell surface mucin glycoprotein expressed by most glandular and ductal epithelial cells and some hematopoietic cell lineages. It is expressed on most secretory epithelium, including mammary gland and some hematopoietic cells. It is expressed abundantly in lactating mammary glands and over expressed abundantly in 90% breast carcinomas and metastases. Transgenic MUC1 has been shown to associate with all four c-erbB receptors and localize with c-erbB1 (EGFR) in lactating glands. The MUC1 gene contains seven exons and produces several different alternatively spliced variants. The major expressed form of MUC1 uses all seven exons and is a type 1 transmembrane protein with a large extracellular tandem repeat domain. The tandem repeat domain is highly O glycosylated and alterations in glycosylation have been shown in epithelial cancer cells. Antibody to EMA

Store at 4°C in the dark. Do not freeze.

Flow Cytometry

SPM492

Flow Cytometry

Breast carcinoma-associated antigen DF3, Carcinoma-associated mucin, CD227, CD227 antigen, DF3 antigen, EMA, episialin, H23 antigen, H23AG, KL-6, MAM6, MUC-1, MUC1/ZD, mucin 1, cell surface associated, mucin 1, transmembrane, mucin-1, Peanut-reactive urinary mucin, PEMMUC-1/SEC, PEMT, Polymorphic epithelial mucin, PUMMUC-1/X, tumor associated epithelial mucin, Tumor-associated epithelial membrane antigen, Tumor-associated mucin

Mouse

Protein A or G purified

Cancer, Cellular Markers, Extracellular Matrix, Inflammation, Signal Transduction

4582.0

Human, Mouse

IgG1 κ