Bcl-2 Antibody (BCL2/2210R), Biotin, Novus Biologicals™

Bcl-2

Monoclonal

Biotin

PBS with 0.05% Sodium Azide

BCL2

Recombinant full-length human bcl-2 protein (Uniprot: P10415)

0.1 mL

Apoptosis, Autophagy, Biologically Active Proteins, Cancer, Cellular Markers, Mitochondrial Mediated Pathway, Mitophagy, Oncogenes, Phospho Specific, Tumor Suppressors

This antibody recognizes a protein of 25-26kDa, identified as the Bcl-2 lpha oncoprotein. It shows no cross-reaction with Bcl-x or Bax protein. Expression of Bcl-2 lpha oncoprotein inhibits the programmed cell death (apoptosis). In most follicular lymphomas, neoplastic germinal centers express high levels of Bcl-2 lpha protein, whereas the normal or hyperplastic germinal centers are negative. Consequently, this antibody is valuable when distinguishing between reactive and neoplastic follicular proliferation in lymph node biopsies. It may also be used in distinguishing between those follicular lymphomas that express Bcl-2 protein and the small number in which the neoplastic cells are Bcl-2 negative.

Store at 4°C in the dark.

Western Blot, Immunohistochemistry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin)

BCL2/2210R

Western Blot, Immunohistochemistry, Immunocytochemistry/Immunofluorescence, Immunohistochemistry-Paraffin

apoptosis regulator Bcl-2, B-cell CLL/lymphoma 2, Bcl-2

Rabbit

Protein A or G purified

RUO

Primary

Human

IgG