TRAF-1 Antibody (TRAF1/2770), Janelia Fluor™ 549, Novus Biologicals™

TRAF-1

Monoclonal

Janelia Fluor 549

50mM Sodium Borate with 0.05% Sodium Azide

TRAF1

Recombinant fragment of human TRAF-1 protein (around aa 73-219) (exact sequence is proprietary) (Uniprot: Q13077)

0.1 mL

Apoptosis, Cancer, Cytokine Research

This monoclonal antibody recognizes a protein of 52kDa, which is identified as TNFR1 (TNFR-associated factor 1). CD30-positive lymphoproliferations of the skin comprise 30% of all primary cutaneous T-cell lymphomas (CTCLs). Besides borderline cases this group includes lymphomatoid papulosis (LyP) and primary cutaneous anaplastic large T-cell lymphoma (cALCL). Although the two entities overlap clinically, histopathologically, immunopathologically and genetically, they differ considerably in their prognosis. In particular, common feature of both cases is histologically the presence of atypical lymphoid CD30-positive T blasts and genetically a clonal T-cell-receptor rearrangement. However, both cases differ considerably in their clinical course: Lesions of LyP regress spontaneously, whereas those of cALCL persist and may progress and spread. Moreover, LyP patients do not benefit from an aggressive radio- and/or chemotherapeutic approach, in contrast to patients with cALCL. Besides, LyP an

Store at 4°C in the dark.

Immunohistochemistry, Immunohistochemistry (Paraffin)

TRAF1/2770

Immunohistochemistry, Immunohistochemistry-Paraffin

EBI6MGC:10353, Epstein-Bar virus-induced protein 6, Epstein-Barr virus-induced protein 6, TNF receptor-associated factor 1

Mouse

Protein A or G purified

RUO

Primary

Human

IgG1 κ