LAG-3 Antibody (C9B7W) - BSA Free, Novus Biologicals™

LAG-3

Monoclonal

1.0 mg/mL

Flow Cytometry 1:50 - 1:200

Q61790

LAG3

Murine CD223 Ig fusion protein

Protein G purified

RUO

Primary

NB100-63601 recognizes murine lymphocyte activation gene-3 (LAG-3), a 70kD activation-induced cell surface molecule that is also referred to as CD223. Murine CD223 is expressed on activated CD4 positive and CD8 positive alpha/beta T lymphocytes and a subset of natural killer (NK) cells. CD223 binds to MHC class II molecules with high affinity and is reported to negatively regulate T cell homeostasis and T cell expansion. Clone C9B7W recognizes an epitope within the D2 domain of CD223. The antibody is reported to block the in vitro function of murine LAG-3 but studies suggest that the antibody does not block binding of LAG-3 to MHC class II (1). 1. Workman, C.J. et al. (2002) Phenotypic analysis of the murine CD4-related glycoprotein, CD223 (LAG-3). Eur J Immunol. 32 (8): 2255-63

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

IgG1

Flow Cytometry

C9B7W

Unconjugated

PBS (pH 7.4) with 0.09% Sodium Azide

CD223, CD223 antigen, FDC, LAG-3, lymphocyte activation gene 3 protein, lymphocyte-activation gene 3, Protein FDC

Rat

57 kDa

0.025 mg

Adaptive Immunity, Immunology, Innate Immunity

3902

Mouse

Purified