Nbs1 Antibody (1D7), Novus Biologicals™

Nbs1

Monoclonal

1.0mg/mL

Western Blot 1:500-1:3000, Simple Western, Immunohistochemistry, Immunocytochemistry/Immunofluorescence 1:100, Immunoprecipitation, Knockdown Validated

ATV, AT-V1, AT-V2, Cell cycle regulatory protein p95, FLJ10155, MGC87362, NBS, NBS1P95, nibrin, Nijmegen breakage syndrome 1 (nibrin), Nijmegen breakage syndrome protein 1, p95, p95 protein of the MRE11/RAD50 complex

Mouse

85 kDa

0.1 mL

Breast Cancer, Cancer, Cell Cycle and Replication, Checkpoint signaling, Chromatin Research, DNA Double Strand Break Repair, DNA Repair, Homologous Recombination, Non homologous end joining, Tumor Suppressors

4683

Human, Mouse, Rat

Purified

Western Blot, Immunohistochemistry, Immunocytochemistry, Immunofluorescence, Immunoprecipitation, KnockDown

1D7

Unconjugated

O60934

NBN

Nbs1 Antibody (1D7) was made to the complete coding region of the human p95/NBS1 expressed in E. coli.

Protein G purified

RUO

Primary

Nijmegen breakage syndrome (NBS, nibrin) is an autosomal recessive chromosomal instability syndrome characterized by microcephaly, growth retardation, immunodeficiency, and cancer predisposition. Nbs1 Antibody (1D7) recognizes the 95kDa NBS protein which contains a fork FHA head-associated domain that is adjacent to BRCT, a breast cancer C terminal domain, that has been implicated in protein-protein interactions. NBS is member of the Mre11/Rad50, p400 double-strand break repair complex involved in double-strand break repair and cell-cycle checkpoint functions.

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

IgG1