MilliporeSigma™ anti-AnkyrinG Clone: 463,
Manufacturer: MilliporeSigma™
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | NB20100UG-Each-of-1 | In Stock | ₹ 45,464.76 |
NB20100UG - Each of 1
In Stock
Quantity
1
Base Price: ₹ 45,464.76
GST (18%): ₹ 8,183.657
Total Price: ₹ 53,648.417
Antigen
AnkyrinG
Classification
Monoclonal
Conjugate
Unconjugated
Host Species
Mouse
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Canine, Human, Mouse, Rat
Form
Purified
Applications
Immunoblot, Immunofluorescence, Immunohistochemistry (Frozen)
Clone
463
Formulation
In 50mM sodium phosphate buffer, 0.2% gelatin, pH 7.5.
Immunogen
a synthetic peptide corresponding to amino acids from the spectrin-binding domain of human ankyrinG
Regulatory Status
RUO
Test Specificity
Recognizes the ∽190kDa ankyrinGprotein in brain extracts. Reacts with all spliced forms of ankyrinG. Antibody Target Gene Symbol: ANK3 Target Synonym: 2900054D09RIK, AI314020, AnkG, Ankyrin-3, ANKYRIN-G, FLJ45464, MGC14049 Entrez Gene Name: ankyrin 3, node of Ranvier (ankyrin G)
Content And Storage
2°C to 8°C
Isotype
IgG1
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Description
- Specifically detects Ankyrin G Clone: 463 in Canine, Human, Mouse, Rat samples, and it is validated for Immunofluorescence, Immunohistochemistry (Frozen), Immuno Blotting Ankyrins are a family of spectrin-binding proteins that couple the spectrin/actin cytoskeletal network to the cytoplasmic domains of integral membrane proteins which include channels such as the anion exchanger, voltage-dependent sodium channel, and the Na/K ATPase, as well as neuronal cell adhesion molecules related to L1
- In the nervous system, three different ankyrins are known to exist; ankyrin B , ankyrin G , and ankyrin R
- All three ankyrins contain an N-terminal membrane binding domain, an internal domain capable of binding spectrin, and a C-terminal regulatory domain which is the target of alternative splicing
- AnkyrinB, the predominant neuronal ankyrin includes two isoforms of ∽220kDa and ∽440kDa
- The ∽220kDa alternatively spliced isoform is the major form present in the adult brain, while the ∽440kDa form is preferentially expressed in the developing neonatal brain
- Three forms of ankyrinG (∽190kDa, ∽270kDa, ∽480kDa) are localized in axonal initial segments and the nodes of Ranvier of myelinated axons where fluxes of action potential occur and ion channels are enriched
- Ankyrins comprise ∽0.5%-1% of the total membrane protein in the adult vertebrate brain.