Filaggrin Antibody (SPM181) - Azide and BSA Free, Novus Biologicals™
Manufacturer: Fischer Scientific
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Antigen
Filaggrin
Classification
Monoclonal
Concentration
1 mg/mL
Dilution
Flow Cytometry 0.5 - 1 ug/million cells, Immunocytochemistry/Immunofluorescence 1 - 2 ug/ml, Immunohistochemistry-Paraffin 0.5 - 1.0 ug/ml, CyTOF-ready
Gene Alias
ATOD2, epidermal filaggrin, filaggrin, Profilaggrin
Host Species
Mouse
Purification Method
Protein A or G purified
Regulatory Status
RUO
Primary or Secondary
Primary
Test Specificity
Filaggrin is an intermediate filament-associated protein that aggregates keratin intermediate filaments in mammalian epidermis. It is initially synthesized as a polyprotein precursor, profilaggrin (consisting of multiple filaggrin units of 324 aa each), which is localized in keratohyalin granules, and is subsequently proteolytically processed into individual functional filaggrin molecules. Active filaggrin is present at a level of the epidermis where keratinocytes are in transition between the live nucleated granular layer and the anucleate cornified layer, suggesting that filaggrin aids in the terminal differentiation process by facilitating apoptotic machinery.
Content And Storage
Store at -20 to -80C. Avoid freeze-thaw cycles.
Isotype
IgG1 κ
Applications
Flow Cytometry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), CyTOF
Clone
SPM181
Conjugate
Unconjugated
Formulation
PBS with No Preservative
Gene Symbols
FLG
Immunogen
Recombinant human Filaggrin protein
Quantity
200 μg
Research Discipline
Cytoskeleton Markers
Gene ID (Entrez)
2312
Target Species
Human
Form
Purified
Related Products
Description
- Filaggrin Monoclonal specifically detects Filaggrin in Human samples
- It is validated for Immunohistochemistry, Immunohistochemistry-Paraffin.