PTH Mouse anti-Human, Clone-PTH/911, Novus Biologicals™

PTH

Monoclonal

1 mg/mL

Flow Cytometry 0.5 - 1 ug/million cells, Immunocytochemistry/Immunofluorescence 0.5 - 1 ug/ml, Immunohistochemistry-Paraffin 0.5 - 1.0 ug/ml, CyTOF-ready

Parathormone, Parathyrin, parathyroid hormone, parathyroid hormone 1, PTH1

Mouse

9 kDa

100 μg

Apoptosis, Biologically Active Proteins, Cancer

5741

Human

IgG2b κ

Flow Cytometry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), CyTOF

PTH/911

Unconjugated

PBS with No Preservative

PTH

A synthetic peptide from the N-terminal of human PTH polypeptide.

Protein A or G purified

RUO

Primary

Epitope of this MAb maps in the N-terminus of PTH, a hormone produced by the parathyroid gland that regulates the concentration of calcium and phosphorus in extracellular fluid. This hormone elevates blood Ca2+ levels by dissolving the salts in bone and preventing their renal excretion.It is produced in the parathyroid gland as an 84 amino acid single chain polypeptide. It can also be secreted as N-terminal truncated fragments or C-terminal fragments after intracellular degradation, as in case of hypercalcemia. Defects in this gene are a cause of familial isolated hypoparathyroidism (FIH); also called autosomal dominant hypoparathyroidism or autosomal dominant hypocalcemia. FIH is characterized by hypocalcemia and hyperphosphatemia due to inadequate secretion of parathyroid hormone. Symptoms are seizures, tetany and cramps. FIH exist both as autosomal dominant and recessive forms of hypoparathyroidism.

Store at -20 to -80C. Avoid freeze-thaw cycles.