P2X7/P2RX7 Antibody (Hano43), DyLight 755, Novus Biologicals™

P2X7/P2RX7

Monoclonal

DyLight 755

ATP receptor, MGC20089, P2X purinoceptor 7, P2X7P2X7 receptor, P2X7R, P2Z receptor, Purinergic receptor, purinergic receptor P2X, ligand-gated ion channel, 7, purinergic receptor P2X7 variant A

Rat

Protein G purified

RUO

5027

Mouse

Purified

Flow Cytometry, Immunocytochemistry, Immunofluorescence

Hano43

Flow Cytometry, Immunocytochemistry/Immunofluorescence

P2RX7

A P2X7-expression construct and a final boost with P2X7-transfected HEK cells.

0.1 mL

Primary

This antibody recognises the P2X purinoceptor 7, also known as P2X7. The P2X7 ATP receptor has a distinctive long C-terminal tail with multiple potential protein and lipid interaction motifs and is highly polymorphic. It is a cation selective ion channel that opens up on binding of extracellular ATP. Sustained activation by extracellular ATP results in the formation of a reversible pore in the plasma membrane that is permeable to hydrophilic solutes of up to 900 Da. Once a pore is opened massive upset of cytoplasmic ion homeostasis occurs and the pore stays open as long as it is bound by ATP. Should ATP stimulation continue the cell will become irreversibly damaged and die. P2X7 plays a key role in the maturation and release of IL-1 and other IL-1 family members during inflammation. As such, P2X7 blockers might be useful as anti-inflammatory agents.

Store at 4C in the dark.

IgG2b