SMPD1 Antibody, Novus Biologicals™

SMPD1

Polyclonal

Western Blot 1:100-1:500, Flow Cytometry, ELISA 1:1000, Immunohistochemistry 1:10-1:50

Acid sphingomyelinase, ASMASE, ASMsphingomyelin phosphodiesterase, EC 3.1.4.12, NPD, sphingomyelin phosphodiesterase 1, acid lysosomal

Rabbit

100 μL

6609

Human

IgG

Western Blot, Flow Cytometry, ELISA, Immunohistochemistry

Unconjugated

PBS (pH 7.2) with 0.09% sodium azide

SMPD1

KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 391-419 in the C-terminal region of human SMPD1, UniProt Accession No.P17405. Species sequence homology: bovine

Primary

The protein encoded by this gene is a lysosomal acid sphingomyelinase that converts sphingomyelin to ceramide. The encoded protein also has phospholipase C activity. Defects in this gene are a cause of Niemann-Pick disease type A (NPA) and Niemann-Pick disease type B (NPB). Multiple transcript variants encoding different isoforms have been identified. [provided by RefSeq].

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.