MAGE 1 Antibody (MA454), DyLight 680, Novus Biologicals™

MAGE 1

Monoclonal

DyLight 680

Antigen MZ2-E, Cancer/testis antigen 1.1, cancer/testis antigen family 1, member 1, CT1.1melanoma antigen family A 1, MAGE-1 antigen, MAGE1A, MAGE1melanoma antigen MAGE-1, melanoma antigen family A, 1 (directs expression of antigen MZ2-E), melanoma-associated antigen 1, melanoma-associated antigen MZ2-E, MGC9326

Mouse

44 kDa

0.1 mL

Apoptosis, Cancer, Melanoma Cell Markers, Tumor Suppressors

4100

Human, Rat, Canine

Purified

ELISA

MA454

ELISA

MAGEA1

Recombinant full-length human MAGE 1 protein (Uniprot: P43355)

Protein A or G purified

RUO

Primary

Recognizes a protein of 42-46kDa, identified as MAGE-1. This monoclonal antibody does not cross-react with MAGE-2, -3, -4, -6 -9, -10, -or -12 protein. Human malignant neoplasms carry rejection antigens that are recognized by the patients' autologous, tumor directed and specific, cytolytic, CD8+ T lymphocyte clones (CTL). The MAGE family of genes codes an important group of antigens. It was identified that melanomas and primary glial brain tumors express common melanoma associated antigens (MAAs). Because MAGE-1 is expressed on a significant proportion of human neoplasms of various histological types (melanoma, brain tumors of glial origin, neuroblastoma, non-small cell lung cancer, breast, gastric, colorectal, ovarian, renal cell carcinomas) and not on normal tissues, the encoded antigen may serve as a marker of early detection and target for cancer immunotherapy.

Store at 4C in the dark.

IgG1 κ