Cyclin D1 Antibody (DCS-6) - Azide and BSA Free, Novus Biologicals™

Cyclin D1

Monoclonal

1.0 mg/mL

Western Blot, Flow Cytometry, ELISA 1-5ug/ml for coating, Immunohistochemistry-Paraffin, CyTOF-ready

CCND1

Human full length recombinant cyclin D1 protein (Uniprot: P24385)

0.1 mg

Cancer, Cell Cycle and Replication, Core ESC Like Genes, mTOR Pathway, Stem Cell Markers, Wnt Signaling Pathway

595

Human, Mouse, Rat, Primate

Purified

Western Blot, Flow Cytometry, ELISA, Immunohistochemistry (Paraffin), CyTOF

DCS-6

Unconjugated

B-cell lymphoma 1 protein, BCL-1, BCL-1 oncogene, BCL1D11S287E, cyclin D1, cyclin D1 (PRAD1: parathyroid adenomatosis 1), G1/S-specific cyclin D1, G1/S-specific cyclin-D1, PRAD1 oncogene, PRAD1B-cell CLL/lymphoma 1, U21B31

Mouse

Protein A or G purified

RUO

Primary

Recognizes a protein of 36kDa, identified as cyclin D1. Cyclin D1, one of the key cell cycle regulators, is a putative proto-oncogene overexpressed in a wide variety of human neoplasms. This antibody neutralizes the activity of cyclin D1 in vivo. About 60% of mantle cell lymphomas (MCL) contain a t(11; 14)(q13; q32) translocation resulting in over-expression of cyclin D1. This antibody is useful in identifying mantle cell lymphomas (cyclin D1 positive) from CLL/SLL and follicular lymphomas (cyclin D1 negative). About 40% of breast carcinomas are positive for Cyclin D1. Occasionally, hairy cell leukemia and plasma cell myeloma weakly express Cyclin D1.

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

IgG2a κ