Plasma Cell Antibody (LIV3G11 (7B18)), Alexa Fluor™ 405, Novus Biologicals™

Plasma Cell

Monoclonal

Alexa Fluor 405

Plasma

Pancreatic cancer related serum mucin was used as the immunogen for the Plasma Cell antibody.

0.1 mL

Immunology

It recognizes an intra-cytoplasmic antigen, which shows a very high degree of specificity for plasma cells. This antigen is present in normal as well as neoplastic plasma cells. Plasma cells, which are large lymphocytes derived from an antigen-specific B cell, secrete antibodies and are responsible for humoral immunity. Plasma cells differentiate from B cells upon stimulation by CD4+ lymphocytes. The B cell acts as an antigen-presenting cell (APC), consuming an offending pathogen, which is taken up by the B cell by phagocytosis and broken down within proteosomes. Plasma cells contain basophilic cytoplasm; their nucleus contains heterochromatin organized in a characteristic cartwheel arrangement. This monoclonal antibody superbly recognizes normal and neoplastic plasma cells in routine formalin-fixed, paraffin-embedded tissue sections. It is of potential value in identifying myeloma or plasmacytoma in bone marrow or other tissues. It also helps differentiate lympho-plasmacytoid lymphoma

Store at 4C in the dark.

IgG2a κ

Immunohistochemistry (Paraffin)

LIV3G11 (7B18)

Immunohistochemistry-Paraffin

Mouse

Protein A or G purified

RUO

Primary

Human, Rat (Negative)

Purified