CD1a Antibody (O10+C1A/711), Alexa Fluor™ 647, Novus Biologicals™

CD1a

Monoclonal

Alexa Fluor 647

CD1, CD1a antigen, CD1A antigen, a polypeptide, CD1a molecule, cluster of differentiation 1 A, cortical thymocyte antigen CD1A, differentiation antigen CD1-alpha-3, epidermal dendritic cell marker CD1a, FCB6, HTA1, hTa1 thymocyte antigen, R4, T6, T-cell surface antigen T6/Leu-6, T-cell surface glycoprotein CD1a

Mouse

49 kDa

0.1 mL

Dendritic Cell Markers, Immunology

909

Human

Purified

Western Blot, Flow Cytometry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Immunohistochemistry (Frozen)

O10+C1A/711

Western Blot, Flow Cytometry, Immunocytochemistry/Immunofluorescence, Immunohistochemistry-Paraffin, Immunohistochemistry-Frozen

CD1A

Human thymus cells (O10); Recombinant human CD1a protein (C1A/711)

Protein A or G purified

RUO

Primary

At least five CD1 genes (CD1a, b, c, d, and e) are identified. CD1 proteins have been demonstrated to restrict T cell response to non-peptide lipid and glycolipid antigens and play a role in non-classical antigen presentation. CD1a is a non-polymorphic MHC Class 1 related cell surface glycoprotein, expressed in association with Beta-2 microglobulin. Anti-CD1a labels Langerhans cell histiocytosis (Histiocytosis X), extranodal histiocytic sarcoma, a subset of T-lymphoblastic lymphoma/leukemia, and interdigitating dendritic cell sarcoma of the lymph node. When combined with antibodies against TTF-1 and CD5, anti-CD1a is useful in distinguishing between pulmonary and thymic neoplasms since CD1a is consistently expressed in thymic lymphocytes in both typical and atypical thymomas, but only focally in 1/6 of thymic carcinomas and not in lymphocytes in pulmonary neoplasms. Anti-CD1a is reported to be a new marker for perivascular epithelial cell tumor (PEComa)

Store at 4C in the dark.

IgG1 κ