DOG1/TMEM16A Antibody (SPM580), DyLight 405, Novus Biologicals™

DOG1/TMEM16A

Monoclonal

DyLight 405

ANO1, anoctamin 1, DOG1, ORAOV2, TAOS2, TMEM16A

Mouse

114 kDa

0.1 mL

Primary

Expression of DOG-1 protein is elevated in the gastrointestinal stromal tumors (GISTs), c-kit signaling-driven mesenchymal tumors of the GI tract. DOG-1 is rarely expressed in other soft tissue tumors, which, due to appearance, may be difficult to diagnose. Immunoreactivity for DOG-1 has been reported in 97.8 percent of scorable GISTs, including all c-kit negative GISTs. Overexpression of DOG-1 has been suggested to aid in the identification of GISTs, including Platelet-Derived Growth Factor Receptor Alpha mutants that fail to express c-kit antigen. The overall sensitivity of DOG1 and c-kit in GISTs is nearly identical: 94.4% vs. 94.7%.

Store at 4C in the dark.

IgG1 κ

Western Blot, Flow Cytometry, ELISA, Immunohistochemistry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Immunohistochemistry (Frozen)

SPM580

Western Blot, Flow Cytometry, ELISA, Immunohistochemistry, Immunocytochemistry/Immunofluorescence, Immunohistochemistry-Paraffin, Immunohistochemistry-Frozen

ANO1

Recombinant human canine1/TMEM16A protein (Uniprot: Q5XX6)

Protein A or G purified

RUO

55107

Human

Purified