beta 2-Microglobulin Antibody (SPM617) - Azide and BSA Free, Novus Biologicals™

beta 2-Microglobulin

Monoclonal

1.0 mg/mL

Flow Cytometry : 0.5 - 1 ug/million cells in 0.1 ml, Immunohistochemistry-Paraffin : 0.5 - 1.0 ug/ml, Flow (Cell Surface) 1:10-1:1000, Immunofluorescence : 0.5 - 1.0 ug/ml, CyTOF-ready

beta chain of MHC class I molecules, beta-2-microglobin, beta-2-microglobulin

Mouse

12 kDa

0.2 mg

Adaptive Immunity, Cancer, Cell Biology, Diabetes Research, Immunology

567

Human, Primate

Purified

Flow Cytometry, Immunohistochemistry (Paraffin), Immunofluorescence, CyTOF

SPM617

Unconjugated

PBS with No Preservative

B2M

Full length recombinant human B2M protein

Protein A or G purified

RUO

Primary

Beta2 microglobulin is a 12KDa protein with a pI of 5.6. Serum beta2 microglobulin levels are a reflection of cell turnover. Levels rise with fever, inflammation, and infection. Increased serum levels are also seen in B-cell malignancies and in renal failure and may indicate a worse prognosis for patients with early-stage Hodgkin's lymphoma. In urine, increased levels are seen in proximal renal tubular disease as well as renal transplant rejection. Beta2 microglobulin levels can rise either because its rate of synthesis has increased (e.g. in AIDS, malignant monoclonal plasma cell dyscrasia, solid tumours and autoimmune disease) or because of impaired renal filtration (e.g. due to renal insufficiency, graft rejection or nephrotoxicity induced by post-transplantation immunosuppressive therapy)

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

IgG1 κ