Cytokeratin 17 Antibody (KRT17/778) - IHC-Prediluted, Novus Biologicals™

Cytokeratin 17

Monoclonal

Unconjugated

10mM PBS and 0.05% BSA with 0.05% Sodium Azide

KRT17

Recombinant full-length human Cytokeratin 17 protein (Uniprot: Q04695)

Protein A or G purified

RUO

Primary

Cytokeratin 17 (CK17) is normally expressed in the basal cells of complex epithelia but not in stratified or simple epithelia. Antibody to CK17 is an excellent tool to distinguish myoepithelial cells from luminal epithelium of various glands such as mammary, sweat and salivary. CK17 is expressed in epithelial cells of various origins, such as bronchial epithelial cells and skin appendages. It may be considered as epithelial stem cell marker because CK17 Ab marks basal cell differentiation. CK17 is expressed in SCLC much higher than in LADC. Eighty-five percent of the triple negative breast carcinomas immunoreact with basal cytokeratins including anti-CK17. Also important is that cases of triple negative breast carcinoma with expression of CK17 show an aggressive clinical course. Additionally, anti-CK17 and anti-MUC1 immunoreactivity represents pancreatobiliary subtype whereas anti-MUC2 and anti-CDX-2 positivity defines intestinal subtype.

Store at 4C.

IgG2b κ

Immunohistochemistry (Paraffin)

KRT17/778

Immunohistochemistry-Paraffin

39.1, CK-17, cytokeratin-17, K17, keratin 17, keratin, type I cytoskeletal 17, keratin-17, PC, PC2, PCHC1

Mouse

46 kDa

7 mL

Cancer

3872

Human, Rat, Porcine, Goat, Primate

Purified