Tyrosinase Antibody (T311 + OCA1/812) - IHC-Prediluted, Novus Biologicals™

Tyrosinase

Monoclonal

Unconjugated

10mM PBS and 0.05% BSA with 0.05% Sodium Azide

TYR

Recombinant tyrosinase protein (Uniprot: P14679 )

Protein A or G purified

RUO

Primary

Recognizes a cluster of proteins between 70-80kDa, identified as tyrosinase. Occasionally a minor band at 55kDa is also detected. This monoclonal antibody shows no cross-reaction with MAGE-1 and tyrosinase-related protein 1, TRP-1/gp75. Tyrosinase is a copper-containing metalloglycoprotein that catalyzes several steps in the melanin pigment biosynthetic pathway; the hydroxylation of tyrosine to L-3,4-dihydroxy-phenylalanine (dopa), and the subsequent oxidation of dopa to dopaquinone. Mutations of the tyrosinase gene occur in various forms of albinism. Tyrosinase is one of the targets for cytotoxic T-cell recognition in melanoma patients. Staining of melanomas with this monoclonal antibody shows tyrosinase in melanotic as well as amelanotic variants. This monoclonal antibody is a useful marker for melanocytes and melanomas.

Store at 4C.

IgG2a κ

Immunohistochemistry (Paraffin)

T311 + OCA1/812

Immunohistochemistry-Paraffin

CMM8, EC 1.14.18.1, LB24-AB, Monophenol monooxygenase, OCA1A, OCAIA, SHEP3, SK29-AB, Tumor rejection antigen AB, tyrosinase, tyrosinase (oculocutaneous albinism IA)

Mouse

75 kDa

7 mL

Lipid and Metabolism

7299

Human

Purified