alpha-Smooth Muscle Actin Antibody (1A4 + ACTA2/791) - IHC-Prediluted, Novus Biologicals™

alpha-Smooth Muscle Actin

Monoclonal

Unconjugated

10mM PBS and 0.05% BSA with 0.05% Sodium Azide

ACTA2

N-Terminal decapeptide of alpha-Smooth Muscle Actin and conjugated to KLH (1A4); Recombinant full-length human ACTA2 protein (ACTA2/791) (Uniprot: P62736)

Protein A or G purified

RUO

Primary

Actin is a major component of the cytoskeleton and is present in most cell types. It is highly specific to actin from smooth muscles. This monoclonal antibody does not stain cardiac or skeletal muscle; however, it does stain myofibroblasts and myoepithelial cells. This antibody could be used together with anti-muscle specific actin and myogenin in making a diagnosis of smooth muscle and skeletal muscle tumors. In most cases of rhabdomyosarcoma, this antibody yields negative results whereas anti-muscle specific actin and myogenin are positive. Leiomyosarcomas are positive only with anti-muscle specific actin and anti-smooth muscle actin and are negative with anti-myogenin.

Store at 4C.

IgG2a κ

Immunohistochemistry (Paraffin)

1A4 + ACTA2/791

Immunohistochemistry-Paraffin

AAT6, actin, alpha 2, smooth muscle, aorta, actin, aortic smooth muscle, ACTSA, ACTVS, alpha 2 actin, alpha SMA, alpha smooth muscle actin, alpha-actin-2, alpha-SMA, a-sma, Cell growth-inhibiting gene 46 protein, growth-inhibiting gene 46, sma, smooth muscle actin

Mouse

42 kDa

7 mL

Angiogenesis, Cancer, Cardiovascular Biology, Cell Biology, Cellular Markers, Developmental Biology, Extracellular Matrix, Signal Transduction, Stem Cell Markers

59

Human, Rat

Purified