Laminin gamma 1 Antibody (A5) - IHC-Prediluted, Novus Biologicals™

Laminin gamma 1

Monoclonal

Unconjugated

10mM PBS and 0.05% BSA with 0.05% Sodium Azide

LAMC1

Murine EHS laminin preparation

Protein A or G purified

RUO

Primary

Laminins are large hetero-trimeric, non-collagenous glycoproteins composed of alpha, beta, and gamma chains. This monoclonal antibody reacts with laminin B2/1 chain of ∼210kDa and does not cross-react with other basement membrane components or fibronectin. Its specificity was established by immunoprecipitation and immunofluorescence of human skeletal muscle and kidney with laminin chain-specific monoclonal antibodys. Epithelial sheets in vivo are separated from the mesenchymal elements of the stroma by a thin layer of a specialized type of extracellular matrix termed the basement membrane (BM). This structure consists of individual components, some of which are ubiquitous in BMs and some are not. The ubiquitous ones comprise laminin (LN), entactin/nidogen (EN), collagen type IV (CIV), and large heparan sulfate proteoglycan (HSPG), which interact specifically with each other to form a continuous and regular BM. Alterations of BM integrity, from local discontinuities up to complete loss, are described in many types of human and animal epithelial neoplasms. This monoclonal antibody stains uniformly all human and murine basement membranes.

Store at 4C.

IgG2a κ

Immunohistochemistry (Paraffin)

A5

Immunohistochemistry-Paraffin

LAMB2Laminin-7 subunit gamma, Laminin B2 chain, laminin subunit gamma-1, laminin, gamma 1 (formerly LAMB2), Laminin-1 subunit gamma, Laminin-10 subunit gamma, Laminin-11 subunit gamma, Laminin-2 subunit gamma, Laminin-3 subunit gamma, Laminin-4 subunit gamma, Laminin-6 subunit gamma, Laminin-8 subunit gamma, Laminin-9 subunit gamma, MGC87297, S-LAM gamma, S-laminin subunit gamma

Rat

210 kDa

7 mL

Apoptosis, Cancer, Cytoskeleton Markers, Extracellular Matrix, Tumor Suppressors

3915

Human, Mouse, Bovine

Purified