Glypican 3 Antibody (1G12) - IHC-Prediluted, Novus Biologicals™

Glypican 3

Monoclonal

Unconjugated

1.0mM PBS and 0.05% BSA with 0.05% Sodium Azide

GPC3

A recombinant fragment containing amino acids 511-580 of human Glypican 3 (Uniprot: P51654)

Protein A or G purified

RUO

2719

Human

Purified

Immunohistochemistry (Paraffin)

1G12

Immunohistochemistry-Paraffin

DGSX, glypican 3, glypican proteoglycan 3, glypican-3, GTR2-2, heparan sulphate proteoglycan, Intestinal protein OCI-5, MXR7, OCI5, OCI-5, secreted glypican-3, SGB, SGBS, SGBS1SDYS

Mouse

67 kDa

7 mL

Primary

Glypican-3 (GPC3) is a glycosylphospatidyl inositol-anchored membrane protein, which may also be found in a secreted form. Anti-GPC3 has been identified as a useful tumor marker for the diagnosis of hepatocellular carcinoma (HCC), hepatoblastoma, melanoma, testicular germ cell tumors, and Wilms tumor and hepatoblastoma, with a low or undetectable expression in normal adjacent tissue. In patients with thyroid cancer, expression of GPC3 is dramatically enhanced in certain types of cancers: 100% in follicular carcinoma and 70% in papillary carcinoma. Expression of GPC3 in follicular carcinoma is significantly higher than that of follicular adenoma. In contrast, GPC3 is not expressed in anaplastic carcinoma.

Store at 4C.

IgG1 κ