RB1 Antibody (1F8), DyLight 488, Novus Biologicals™

RB1

Monoclonal

DyLight 488

50 mM sodium borate with 0.05% sodium azide

RB1

Recombinant human RB1 protein fragment of 283 amino acid residues. (Uniprot: P06400)

0.1 mL

Primary

Recognizes a 105kDa phosphoprotein, identified as retinoblastoma (Rb) gene product. Its epitope is localized between aa 703-772. It shows no cross reaction with p107 or p130. It specifically stains the nuclei of BT-20 cells and primary human foreskin fibroblast (HFF) cells. It does not stain the Rb-negative BT549 cells. It reacts with the hyperphosphorylated as well as the un (under) phosphorylated form of the Rb protein. Retinoblastoma gene product plays a key role in cell cycle control. It has been identified as a tumor suppressor gene whose loss of its function leads to tumor development. It is widely expressed in a variety of human tissues including breast, esophageal, squamous cell and cervical carcinoma.

Store at 4°C in the dark.

Western Blot, Immunohistochemistry, Immunohistochemistry (Paraffin)

1F8

Western Blot, Immunohistochemistry, Immunohistochemistry-Paraffin

OSRC, osteosarcoma, p105-Rb, pp110, pRb, Rb, retinoblastoma 1, retinoblastoma suspectibility protein, retinoblastoma-associated protein

Mouse

Protein A or G purified

Cancer, Cell Cycle and Replication, Phospho Specific, Transcription Factors and Regulators, Tumor Suppressors

5925.0

Human, Mouse

IgG1 κ