PAX8 Antibody (PAX8/1492), DyLight 488, Novus Biologicals™

PAX8

Monoclonal

DyLight 488

50 mM sodium borate with 0.05% sodium azide

PAX8

Recombinant fragment (around aa 60-261) of human PAX8 protein (exact sequence is proprietary) (Uniprot: Q06710)

0.1 mL

Primary

Recognizes a protein of 62kDa, identified as PAX8. It is a member of the paired box (PAX) family of transcription factors. This nuclear protein is involved in thyroid follicular cell development and expression of thyroid-specific genes. Mutations in this gene have been associated with thyroid dysgenesis, thyroid follicular carcinomas, and atypical thyroid adenomas. PAX-8 is expressed in the thyroid (and associated carcinomas), non-ciliated mucosal cells of the fallopian tubes, and simple ovarian inclusion cysts, but not normal ovarian surface epithelial cells. PAX-8 is expressed in a high percentage of ovarian serous, endometrioid, and clear cell carcinomas, but only rarely in primary ovarian mucinous adenocarcinomas. PAX-8 expression is reported in renal tubules as well as renal cell carcinoma, nephroblastoma, and seminoma. PAX-8 antibody may be used as an additional immunohistochemical marker for renal epithelial tumors.

Store at 4°C in the dark.

Western Blot, Flow Cytometry, Immunohistochemistry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin)

PAX8/1492

Western Blot, Flow Cytometry, Immunohistochemistry, Immunocytochemistry/Immunofluorescence, Immunohistochemistry-Paraffin

paired box 8, paired box gene 8, paired box protein Pax-8, paired domain gene 8

Mouse

Protein A or G purified

Cancer

7849.0

Human

IgG2b κ