CD25/IL-2R alpha Antibody (Basiliximab), DyLight 755 - Chimeric, Novus Biologicals™

CD25/IL-2R alpha

Monoclonal

DyLight 755

50mM Sodium Borate with 0.05% Sodium Azide

IL2RA

Basiliximab was prepared by immunizing BALB/c mice with CTC 16 cells.

0.1 mL

Primary

Basiliximab recognises the human IL-2R and binds to the epitope (116)ERIYHFV(122) within the extracellular domain of the CD25 subunit -binding is abolished when 2 or more residues within the epitope are mutated. This epitope overlaps with the interaction site of CD25 and IL-2. CD25 is found in the high-affinity IL-2R ((alpha)(beta)(gamma)c) -T cells only express CD25 upon activation. IL-2 binding to IL-2R on T cells modulates proliferation and differentiation.

Store at 4°C in the dark.

Western Blot, Flow Cytometry, Immunohistochemistry, Immunofluorescence

Basiliximab

Western Blot, Flow Cytometry, Immunohistochemistry, Immunofluorescence

CD25, CD25 antigen, IDDM10, IL-2 receptor subunit alpha, IL2R, IL-2R subunit alpha, IL-2-RA, IL2-RA, interleukin 2 receptor, alpha, interleukin-2 receptor subunit alpha, p55, TAC antigen, TCGFR

Human

Protein A purified

Adaptive Immunity, Apoptosis, B Cell Development and Differentiation Markers, Biologically Active Proteins, Cytokine Research, Diabetes Research, Immunology, Innate Immunity, Mast Cell Markers, Signal Transduction

3559.0

Human, Cynomolgus Monkey, Rhesus Macaque

IgG1 κ