p21/CIP1/CDKN1A Antibody (CIP1/823 + DCS-60.2), Biotin, Novus Biologicals™

p21/CIP1/CDKN1A

Monoclonal

Biotin

PBS with 0.05% Sodium Azide

CDKN1A

Recombinant full-length human p21/CIP1/CDKN1A protein (CIP1/823); Human recombinant p21 protein (DCS-60.2) (Uniprot: P38936)

0.1 mL

Primary

This monoclonal antibody recognizes a 21kDa protein, identified as the p21WAF1 tumor suppressor protein. This monoclonal antibody is highly specific to p21 and shows no cross-reaction with other closely related mitotic inhibitors. p21WAF1 is a specific inhibitor of cdks and a tumor suppressor involved in the pathogenesis of a variety of malignancies. The expression of this gene acts as an inhibitor of the cell cycle during G1 phase and is tightly controlled by the tumor suppressor protein p53. Its expression is induced by the wild type, but not mutant, p53 suppressor protein. Normal cells generally display a rather intense nuclear p21 expression. Loss of p21 expression has been reported in many carcinomas (gastric carcinoma, non-small cell lung carcinoma, thyroid carcinoma).

Store at 4C in the dark.

IgG2a κ

Western Blot, Flow Cytometry, Immunohistochemistry, Immunohistochemistry (Paraffin)

CIP1/823 + DCS-60.2

Western Blot, Flow Cytometry, Immunohistochemistry, Immunohistochemistry-Paraffin

CAP20cyclin-dependent kinase inhibitor 1, CDK-interacting protein 1, CDKN1melanoma differentiation associated protein 6, CIP1WAF1CDK-interaction protein 1, cyclin-dependent kinase inhibitor 1A (p21, Cip1), MDA6, MDA-6, Melanoma differentiation-associated protein 6, p21, p21CIP1, p21Cip1/Waf1, PIC1, SDI1DNA synthesis inhibitor, wild-type p53-activated fragment 1

Mouse

Protein A or G purified

Apoptosis, Breast Cancer, Cancer, Cell Cycle and Replication, DNA Repair, Phospho Specific

1026

Human, Mouse (Negative), Rat (Negative)

Purified