CD63 Antibody (NKI/C3 + LAMP3/968), Biotin, Novus Biologicals™

CD63

Monoclonal

Biotin

PBS with 0.05% Sodium Azide

CD63

Smooth plasma membrane fraction of MeWo cells (NKI/C3); Recombinant human full-length CD63 protein (LAMP3/968)

0.1 mL

Primary

This monoclonal antibody recognizes protein of 26kDa-60kDa, which is identified as CD63. The tetraspanins are integral membrane proteins expressed on cell surface and granular membranes of hematopoietic cells and are components of multi-molecular complexes with specific integrins. The tetraspanin CD63 is a lysosomal membrane glycoprotein that translocates to the plasma membrane after platelet activation. CD63 is expressed on activated platelets, monocytes and macrophages, and is weakly expressed on granulocytes, T cell and B cells. It is located on the basophilic granule membranes and on the plasma membranes of lymphocytes and granulocytes. CD63 is a member of the TM4 superfamily of leukocyte glycoproteins that includes CD9, CD37 and CD53, which contain four transmembrane regions. CD63 may play a role in phagocytic and intracellular lysosome-phagosome fusion events. CD63 deficiency is associated with Hermansky-Pudlak syndrome and is strongly expressed during the early stages of melanom

Store at 4C in the dark.

IgG1 κ

Flow Cytometry, Immunohistochemistry, Immunohistochemistry (Paraffin), Immunofluorescence

NKI/C3 + LAMP3/968

Flow Cytometry, Immunohistochemistry, Immunohistochemistry-Paraffin, Immunofluorescence

CD63 antigen, CD63 antigen (melanoma 1 antigen), CD63 molecule, Granulophysin, LAMP-3, Lysosomal-associated membrane protein 3, ME491, melanoma 1 antigen, Melanoma-associated antigen ME491, melanoma-associated antigen MLA1, MLA1lysosome-associated membrane glycoprotein 3, Ocular melanoma-associated antigen, OMA81H, Tetraspanin-30, tspan-30, TSPAN30granulophysin

Mouse

Protein A or G purified

Autophagy, Cancer, Cardiovascular Biology, Cytokine Research, Immunology, Innate Immunity, Lysosome Markers, Metastasis

967

Human

Purified