c-Myb Antibody (MYB286), Alexa Fluor™ 594, Novus Biologicals™

c-Myb

Monoclonal

Alexa Fluor 594

50 mM sodium borate with 0.05% sodium azide

MYB

A synthetic peptide, corresponding to aa 119-135 (RRKVEQEGYPQESSKAG) of c-myb onco protein, coupled to KLH (Uniprot: P01104)

0.1 mL

4602

Human

IgG1 κ

Western Blot, Flow Cytometry, ELISA, Immunocytochemistry, Immunofluorescence

MYB286

Western Blot, Flow Cytometry, ELISA, Immunocytochemistry/Immunofluorescence

c-myb, Cmyb, c-myb protein (140 AA), c-myb_CDS, c-myb10A_CDS, c-myb13A_CDS, c-myb14A_CDS, c-myb8B_CDS, efg, Proto-oncogene c-Myb, transcriptional activator Myb, v-myb avian myeloblastosis viral oncogene homolog, v-myb myeloblastosis viral oncogene homolog (avian)

Mouse

Protein A or G purified

Primary

The highly leukemogenic avian retrovirus E26 contains two oncogenes, v-Myb and v-Ets, which are expressed together as a fusion protein. The cellular homolog of v-Myb, designated c-Myb, encodes a transcription factor. Deletion or disruption of a negative regulatory domain mapping within the carboxy-terminal domain of c-Myb results in enhanced transactivating capacity and in parallel, leads to activation of its ability to transform hemopoietic cells. c-Myb is expressed preferentially, but not exclusively, in immature hemopoietic cells and its expression decreases as cells differentiate.

Store at 4°C in the dark.