Thyroglobulin Antibody (TGB04 + TGB05), Alexa Fluor™ 594, Novus Biologicals™

Thyroglobulin

Monoclonal

Alexa Fluor 594

50 mM sodium borate with 0.05% sodium azide

TG

Human thyroid follicular cells

0.1 mL

7038

Human, Mouse, Rat

IgG1 κ

Western Blot, Flow Cytometry, Immunohistochemistry, Immunohistochemistry (Paraffin)

TGB04 + TGB05

Western Blot, Flow Cytometry, Immunohistochemistry, Immunohistochemistry-Paraffin

AITD3TGN, TDH3, Tg, thyroglobulin

Mouse

Protein A or G purified

Primary

Thyroglobulin is a 660kDa dimeric pre-protein with multiple glycosylation sites. It is produced by and processed within the thyroid gland to produce the hormone thyroxine and triiodothyronine. Prior to forming dimers, thyroglobulin monomers undergo conformational maturation in the endoplasmic reticulation. The vast majority of follicular carcinomas of the thyroid will give positive immunoreactivity for anti-thyroglobulin even though sometimes only focally. Poorly differentiated carcinomas of the thyroid are frequently anti-thyroglobulin negative. Adenocarcinomas of other-than-thyroid origin do not react with this antibody. This antibody is useful in identification of thyroid carcinoma of the papillary and follicular types. Presence of thyroglobulin in metastatic lesions establishes the thyroid origin of tumor. Anti-thyroglobulin, combined with anti-calcitonin, can identify medullary carcinomas of the thyroid. Furthermore, anti-thyroglobulin, combined with anti-TTF1, can be a reliable m

Store at 4°C in the dark.