PTH Antibody (3H9), Alexa Fluor™ 532 - N-terminal, Novus Biologicals™

PTH

Monoclonal

Alexa Fluor 532

50 mM sodium borate with 0.05% sodium azide

PTH

A synthetic peptide around aa 1-34 of human mature-PTH-polypeptide (exact sequence is proprietary) (Uniprot: P01270)

0.1 mL

Primary

Epitope of this monoclonal antibody maps in between aa 1-34. PTH is a hormone produced by the parathyroid gland that regulates the concentration of calcium and phosphorus in extracellular fluid. This hormone elevates blood Ca2+ levels by dissolving the salts in bone and preventing their renal excretion. It is produced in the parathyroid gland as an 84 amino acid single chain polypeptide. It can also be secreted as N-terminal truncated fragments or C-terminal fragments after intracellular degradation, as in case of hypercalcemia. Defects in this gene are a cause of familial isolated hypoparathyroidism (FIH); also called autosomal dominant hypoparathyroidism or autosomal dominant hypocalcemia. FIH is characterized by hypocalcemia and hyperphosphatemia due to inadequate secretion of parathyroid hormone. Symptoms are seizures, tetany and cramps. FIH exist both as autosomal dominant and recessive forms of hypoparathyroidism.

Store at 4°C in the dark.

Flow Cytometry, Immunohistochemistry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin)

3H9

Flow Cytometry, Immunohistochemistry, Immunocytochemistry/Immunofluorescence, Immunohistochemistry-Paraffin

Parathormone, Parathyrin, parathyroid hormone, parathyroid hormone 1, PTH1

Mouse

Protein A or G purified

Apoptosis, Biologically Active Proteins, Cancer

5741.0

Human

IgG2b κ