ALK/CD246 Antibody (ALK/1503), Alexa Fluor™ 350, Novus Biologicals™

ALK/CD246

Monoclonal

Alexa Fluor 350

50 mM sodium borate with 0.05% sodium azide

ALK

Recombinant human ALK/CD246 protein fragment (aa1360-1460) (Uniprot: Q9UM73 )

0.1 mL

Primary

The wild-type anaplastic lymphoma kinase (ALK) protein is a 200kDa transmembrane receptor tyrosine kinase. Its expression is restricted to a few scattered cells in the nervous system (some glial cells and neurons, and a few endothelial cells and pericytes. The hybrid gene,NPM-ALK, created by the t(2;5)(p23;q35) chromosomal translocation encodes part of the nucleolar phosphoprotein, nucleophosmin (NPM), joined to the entire cytoplasmic portion of the anaplastic lymphoma kinase (ALK) receptor tyrosine kinase. As a consequence, the ALK gene comes under the control of the NPM promoter, which induces a permanent and ubiquitous transcription of the NPM-ALK hybrid gene, resulting in the production of a 80kDa NPM-ALK chimeric protein. This translocation is found in anaplastic large cell lymphomas (ALCL). Reportedly, expression of ALK indicates a better prognosis. Approximately 5%-10% of non-small cell lung carcinomas also express ALK protein producing a cytoplasmic staining pattern. This monoc

Store at 4°C in the dark.

Western Blot, Flow Cytometry, Immunocytochemistry, Immunofluorescence

ALK/1503

Western Blot, Flow Cytometry, Immunocytochemistry/Immunofluorescence

ALK tyrosine kinase receptor, Anaplastic lymphoma kinase, anaplastic lymphoma kinase (Ki-1), anaplastic lymphoma receptor tyrosine kinase, CD246, CD246 antigen, EC 2.7.10.1, NBLST3

Mouse

Protein A or G purified

Phospho Specific, Protein Kinase, Signal Transduction

238.0

Human

IgG1 κ