Alkaline Phosphatase/ALPP Antibody (ALPP/516), Alexa Fluor™ 594, Novus Biologicals™

Alkaline Phosphatase/ALPP

Monoclonal

Alexa Fluor 594

50 mM sodium borate with 0.05% sodium azide

ALPP

Recombinant full-length human Alkaline Phosphatase/ALPP protein (Uniprot: P05187)

Primary

PLAP is a tissue specific, trophoblast-derived, 70kDa, glycosyl-phosphatidylinositol (GPI)-anchored, dimeric, Zn2+ metallo-glycoprotein that catalyzes the hydrolysis of phosphomonoesters into an inorganic phosphate and an alcohol. It is present in the placenta and serum of pregnant women and in high frequency in gynecological and testicular cancers and in lower frequency in other tumors. The three tissue-specific APs in humans, PLAP, germ cell AP (GCAP) and intestinal AP, are 90-98% homologous. Non-tissue specific AP is found in kidney, liver and bone. This monoclonal antibody binds equally well to all common allelic variants (S, F, FS and I) of PLAP and to some variants of AP from normal human testis. This monoclonal antibody can be used as tracer antibody in ELISA to detect PLAP in serum of S, F, FS and I phenotypes.

Store at 4°C in the dark.

Flow Cytometry, Immunohistochemistry, Immunohistochemistry (Frozen), Immunofluorescence

ALPP/516

Flow Cytometry, Immunohistochemistry, Immunohistochemistry-Frozen, Immunofluorescence

Alkaline phosphatase Regan isozyme, alkaline phosphatase, placental, alkaline phosphatase, placental (Regan isozyme), alkaline phosphatase, placental type, alkaline phosphomonoesterase, ALP, EC 3.1.3.1, FLJ61142, glycerophosphatase, PALP, Placental alkaline phosphatase 1, PLAP, PLAP-1, Regan isozyme

Mouse

0.1 mL

250

Human

IgG1 κ