Alkaline Phosphatase, Tissue Non-Specific Antibody (V17.1), Alexa Fluor™ 350, Novus Biologicals™

Alkaline Phosphatase, Tissue Non-Specific

Monoclonal

Alexa Fluor 350

50 mM sodium borate with 0.05% sodium azide

ALPL

Bovine alkaline phosphatase (Uniprot: P05186)

0.1 mL

Primary

There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The first three are located together on chromosome 2, while the tissue non-specific form is located on chromosome 1. The product of this gene is a membrane bound glycosylated enzyme that is not expressed in any particular tissue and is, therefore, referred to as the tissue-nonspecific form of the enzyme. The exact physiological function of the alkaline phosphatases is not known. A proposed function of this form of the enzyme is matrix mineralization; however, mice that lack a functional form of this enzyme show normal skeletal development. This enzyme has been linked directly to hypo-phosphatasia, a disorder that is characterized by hypercalcemia and includes skeletal defects. The character of this disorder can vary, however, depending on the specific mutation since this determines age of onset and severity of symptoms. Alternatively sp

Store at 4°C in the dark.

Flow Cytometry, Immunohistochemistry, Immunohistochemistry (Frozen), Immunofluorescence

V17.1

Flow Cytometry, Immunohistochemistry, Immunohistochemistry-Frozen, Immunofluorescence

Alkaline phosphatase liver/bone/kidney isozyme, alkaline phosphatase, liver/bone/kidney, alkaline phosphatase, tissue-nonspecific isozyme, alkaline phosphomonoesterase, APTNAP, AP-TNAP, EC 3.1.3.1, FLJ40094, FLJ93059, glycerophosphatase, HOPS, liver/bone/kidney-type alkaline phosphatase, MGC161443, tissue-nonspecific ALP, TNAP, TNSALPMGC167935

Mouse

Protein A or G purified

Cancer, Embryonic Stem Cell Markers, Lipid and Metabolism, Protein Phosphatase, Stem Cell Markers

249.0

Human, Primate

IgG1 κ