OP24100UG
MilliporeSigma™ anti-c-K-Ras Clone: 234-4.2,
Manufacturer: MilliporeSigma™
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | OP24100UG-Each-of-1 | In Stock | ₹ 48,594.00 |
OP24100UG - Each of 1
In Stock
Quantity
1
Base Price: ₹ 48,594.00
GST (18%): ₹ 8,746.92
Total Price: ₹ 57,340.92
Antigen
c-K-Ras
Classification
Monoclonal
Conjugate
Unconjugated
Host Species
Mouse
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Form
Purified
Applications
Immunoblot, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Immunoprecipitation
Clone
234-4.2
Formulation
In 50mM sodium phosphate buffer, 0.2% gelatin, pH 7.5.
Immunogen
recombinant, rat K-Ras
Regulatory Status
RUO
Test Specificity
Recognizes c-K-Ras and v-K-Ras in SW480 and Y1 cells and normal skin tissue. Cross-reacts with c-H-Ras and c-N-Ras.
Content And Storage
2°C to 8°C
Isotype
IgG2a
Related Products
Description
- Specifically detects c-K-Ras Clone: 234-4.2 in Human, Mouse, Rat samples, and it is validated for Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Immunoprecipitation, Immuno Blotting The human ras gene family consists of three identified members, H, K and N-ras, encoding proteins of 188-189 amino acids and 21,000 (p21) molecular weight
- Human H- and K-ras are the homologues of v-H- and v-K-ras sequences originally isolated from Harvey and Kirsten strains of rat sarcoma viruses
- Normal human cellular ras genes can be activated to oncogenes by mutations occurring in codons 12, 13 and 61; such mutated, activated and transforming ras genes have been identified and isolated from human tumors and cultured tumor cells
- Although the expression patterns of Ras proteins in normal human tissues are known, similar information for activated ras oncogene encoded p21s and their relevance to human disease diagnosis and prognosis is still emerging
- K-ras mutations have been identified in several cancers to date including lung and colorectal tumors.