MilliporeSigma™ anti-p53 (Mutant) Clone: PAb240,
Manufacturer: MilliporeSigma™
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | OP29L100UG-Each-of-1 | In Stock | ₹ 42,114.80 |
OP29L100UG - Each of 1
In Stock
Quantity
1
Base Price: ₹ 42,114.80
GST (18%): ₹ 7,580.664
Total Price: ₹ 49,695.464
Antigen
p53 (Mutant)
Classification
Monoclonal
Conjugate
Unconjugated
Host Species
Mouse
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Bovine, Chicken, Hamster, Human, Mouse, Rat
Form
Purified
Applications
Flow Cytometry, Gel Supershift, Immunoblot, Immunoblot, Immunofluorescence, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Immunoprecipitation
Clone
PAb240
Formulation
In 50mM sodium phosphate buffer, 0.2% gelatin, pH 7.5.
Immunogen
a recombinant protein consisting of amino acids 14-389 of p53 fused to β-galactosidase
Regulatory Status
RUO
Test Specificity
Recognizes the ∽53kDa mutant p53 protein under non-denaturing conditions by immunoprecipitation, immunofluorescence, and flow cytometry. Recognizes both mutant and wild-type p53 by immunoblotting and paraffin sections under denaturing conditions.
Content And Storage
2°C to 8°C
Isotype
IgG1
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Description
- Specifically detects p53 (Mutant) Clone: PAb240 in Bovine, Chicken, Hamster, Human, Mouse, Rat samples, and it is validated for Flow Cytometry, Gel Supershift, Immunofluorescence, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Immunoprecipitation, Immuno Blotting The human p53 tumor suppressor gene encodes a 393 amino acid phosphoprotein that exhibits sequence-specific DNA binding and directly interacts with various cellular and viral proteins
- p53 is the most commonly mutated gene in human cancer, with the majority of the mutations being amino acid substitutions
- The normal function of p53 is to effect cell cycle arrest at the G1 and G2 checkpoints in response to DNA damage
- This checkpoint function is executed by accumulation of p53 followed by induction of the GADD45, WAF1 and MDM2 genes
- The current model of p53 function postulates that p53 senses DNA damage and arrests the cell cycle in either the G1 or G2 phases to allow DNA repair to take place
- If repair is not successful, p53 initiates programmed cell death, thus preventing the propagation of genetic defects to successive generations of cells.