CD40 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PA131075-Each-of-1 | In Stock | ₹ 49,350.50 |
PA131075 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 49,350.50
GST (18%): ₹ 8,883.09
Total Price: ₹ 58,233.59
Antigen
CD40
Classification
Polyclonal
Conjugate
Unconjugated
Gene
CD40
Gene Alias
AI326936; B cell surface antigen CD40; B cell-associated molecule; B-cell surface antigen CD40; Bp50; CD antigen CD40; Cd40; CD40 antigen; CD40 antigen (TNF receptor superfamily member 5); CD40 antigen, TNF receptor superfamily member 5; CD40 molecule; CD40 molecule, TNF receptor superfamily member 5; CD40L receptor; CDw40; GP39; HIGM1; I79_006806; IGM; IMD3; Immunoglobulin M; ImmunoglobulinM; membrane protein CD40; MGC9013; p50; receptor for ligand CD154; sCD40; soluble CD40; T-BAM; T-cell differentiation antigen; Tnfrsf5; TRAP; tumor necrosis factor receptor superfamily member 5; tumor necrosis factor receptor superfamily, member 5
Host Species
Rabbit
Purification Method
Antigen affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
100349106, 100728791, 100770242, 171369, 21939, 397395, 403469, 443232, 958
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Applications
Western Blot
Concentration
1 mg/mL
Formulation
PBS with 50% glycerol and 0.09% sodium azide
Gene Accession No.
P25942, P27512, Q7YRL5, Q8SQ34
Gene Symbols
CD40
Immunogen
synthetic peptide CQPVTQEDGKESRISVQERQ conjugated to KLH, corresponding to amino acids 258-277 of Human CD40.
Quantity
50 μg
Primary or Secondary
Primary
Target Species
Canine, Guinea Pig, Hamster, Human, Mouse, Non-human Primate, Ovine, Porcine, Rabbit, Rat
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Recommended positive controls: Rat Testes Tissue Extract
- Store product as a concentrated solution
- Centrifuge briefly prior to opening the vial
- The CD40 antigen is a single chain glycoprotein that is known to be a member of the tumor necrosis factor/nerve growth factor superfamily and shows a significant homology to the Hodgkin's disease associated antigen, CD30
- CD40 is present on all B cells except plasma cells and is also found on some epithelial cells, carcinomas and lymphoid dendritic cells
- CD40 has been found to be essential in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation
- AT-hook transcription factor AKNA is reported to coordinately regulate the expression of CD40, which may be important for homotypic cell interactions
- Adaptor protein TNFR2 interacts with CD40 and serves as a mediator of the signal transduction
- The interaction of CD40 and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis
- Two alternatively spliced transcript variants of CD40 encoding distinct isoforms have been reported
- Diseases associated with CD40 dysfunction include Type 3 Hyper-Igm immunodeficiency and CD40 ligand deficiency.