PA173137
Diphtheria Toxin Polyclonal Antibody, FITC, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PA173137-Each-of-1 | In Stock | ₹ 49,706.50 |
PA173137 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 49,706.50
GST (18%): ₹ 8,947.17
Total Price: ₹ 58,653.67
Antigen
Diphtheria Toxin
Classification
Polyclonal
Conjugate
FITC
Gene Alias
DT
Immunogen
Purified diphtheria toxoid.
Quantity
1 mL
Primary or Secondary
Primary
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Store in the dark.
Form
Liquid
Applications
Immunocytochemistry
Concentration
4-5 mg/mL
Formulation
PBS with 10mg/mL BSA and 0.1% sodium azide; pH 7.2
Host Species
Goat
Purification Method
IgG fraction
Regulatory Status
RUO
Target Species
Bacteria
Product Type
Antibody
Isotype
IgG
Related Products
Description
- The PA1-73137 antibody reacts with Diphtheria toxin
- PA1-73137 has been successfully used in Immunofluorescence applications
- The PA1-73137 antibody was raised against purified diphtheria toxoid
- Diphtheria toxin is a 58 kDa protein secreted by lysogenic strains of Corynebacterium diphtheriae
- The toxin causes the disease diphtheria in humans by gaining entry into the cell cytoplasm and inhibiting protein synthesis
- The mechanism of inhibition involves transfer of the ADP-ribose group of NAD to elongation factor-2 (EF-2), rendering EF-2 inactive
- The catalysed reaction is as follows: NAD + + peptide diphthamide = nicotinamide + peptide N-(ADP-D-ribosyl)diphthamide The crystal structure of the diphtheria toxin homodimer has been determined to 2.5A resolution
- The structure reveals a Y-shaped molecule of 3 domains, a catalytic domain (fragment A), whose fold is of the alpha + beta type; a transmembrane (TM) domain, which consists of 9 alpha-helices, 2 pairs of which may participate in pH-triggered membrane insertion and translocation; and a receptor-binding domain, which forms a flattened beta-barrel with a jelly-roll-like topology
- The TM- and receptor binding-domains together constitute fragment B.